Uncovering the Early Events Associated with Oligomeric Aβ-Induced Src Activation.

ABSTRACT: Soluble Aβ_1-42 oligomers (AβO) are formed in the early stages of Alzheimer's disease (AD) and were previously shown to trigger enhanced Ca²⁺ levels and mitochondrial dysfunction via the activation of N-methyl-D-aspartate receptors (NMDAR). Src kinase is a ubiquitous redox-sensitive non-receptor tyrosine kinase involved in the regulation of several cellular processes, which was demonstrated to have a reciprocal interaction towards NMDAR activation. However, little is known about the early-stage mechanisms associated with AβO-induced neurodysfunction involving Src. Thus, in this work, we analysed the influence of brief exposure to oligomeric Aβ_1-42 on Src activation and related mechanisms involving mitochondria and redox changes in mature primary rat h

SUBMITTER: Mota SI 

PROVIDER: S-EPMC10525724 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature