A Systematic Review on the Clinical Pharmacokinetics of Cephalexin in Healthy and Diseased Populations.

ABSTRACT: Cephalexin is a first-generation β-lactam antibiotic used in adults and pediatrics to treat various streptococcal and staphylococcal infections. This review aims to summarize and evaluate all the pharmacokinetic (PK) data on cephalexin by screening out all pertinent studies in human beings following the per oral (PO) route. By employing different online search engines such as Google Scholar, PubMed, Cochrane Central, and Science Direct, 23 studies were retrieved, among which nine were in healthy subjects, five in diseased ones, and the remaining were drug-drug, drug-food, and bioequivalence-related. These studies were included only based on the presence of plasma concentration-time profiles or PK parameters, i.e., maximum plasma concentration (C_max), half-life (t_1/2)

SUBMITTER: Kanan M 

PROVIDER: S-EPMC10526061 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature