Decreased Klotho Expression Causes Accelerated Decline of Male Fecundity through Oxidative Injury in Murine Testis.

ABSTRACT: Oxidative stress is the etiology for 30-80% of male patients affected by infertility, which is a major health problem worldwide. Klotho protein is an aging suppressor that functions as a humoral factor modulating various cellular processes including antioxidation and anti-inflammation, and its dysregulation leads to human pathologies. Male mice lacking Klotho are sterile, and decreased Klotho levels in the serum are observed in men suffering from infertility with lower sperm counts. However, the mechanism by which Klotho maintains healthy male fertility remains unclear. Klotho haplodeficiency (Kl^+/-) accelerates fertility reduction by impairing sperm quality and spermatogenesis in Kl^+/- mice. Testicular proteomic analysis revealed that loss of Klo

SUBMITTER: Wang YY 

PROVIDER: S-EPMC10526093 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature