Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.

ABSTRACT: Liver fibrosis is a major challenge to global health because of its various complications, including cirrhosis and hepatocarcinoma, while no effective treatment is available for it. Sappanone A (SA) is a homoisoflavonoid extracted from the heartwood of Caesalpinia sappan Linn. with anti-inflammatory and antioxidant properties. However, the effects of SA on hepatic fibrosis remain unknown. This study aimed to investigate the protective effects of SA on carbon tetrachloride (CCl₄)-induced liver fibrosis in mice. To establish a liver fibrosis model, mice were treated intraperitoneally (i.p.) with CCl₄ for 4 weeks. SA (25, 50, and 100 mg/kg body weight) was i.p. injected every other day during the same period. Our data indicated that SA decreased liver injury, fibr

SUBMITTER: Qi J 

PROVIDER: S-EPMC10526100 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature