Mechanisms of Resistance to Small Molecules in Acute Myeloid Leukemia.
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ABSTRACT:
SUBMITTER: Lang TJL
PROVIDER: S-EPMC10526197 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Publications
Mechanisms of Resistance to Small Molecules in Acute Myeloid Leukemia.
Lang Tonio Johannes Lukas TJL Damm Frederik F Bullinger Lars L Frick Mareike M
Cancers 20230915 18
In recent years, great progress has been made in the therapy of AML by targeting cellular processes associated with specific molecular features of the disease. Various small molecules inhibiting FLT3, IDH1/IDH2, and BCL2 have already gained approval from the respective authorities and are essential parts of personalized therapeutic regimens in modern therapy of AML. Unfortunately, primary and secondary resistance to these inhibitors is a frequent problem. Here, we comprehensively review the curr ...[more]
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