Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors.

ABSTRACT: Research has shown the role of growth factors in lung cancer angiogenesis. Angiogenesis promotes lung cancer progression by stimulating tumor growth, enhancing tumor invasion, contributing to metastasis, and modifying immune system responses within the tumor microenvironment. As a result, new treatment techniques based on the anti-angiogenic characteristics of compounds have been developed. These compounds selectively block the growth factors themselves, their receptors, or the downstream signaling pathways activated by these growth factors. The EGF and VEGF families are the primary targets in this approach, and several studies are being conducted to propose anti-angiogenic drugs that are increasingly suitable for the treatment of lung cancer, either as monotherapy or as combined therapy.

SUBMITTER: Ngaha TYS 

PROVIDER: S-EPMC10526378 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature