Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky-Molodkina Rats.

ABSTRACT: Epilepsy or epileptic syndromes affect more than 70 million people, often comorbid with autism spectrum disorders (ASD). Seizures are concerned as a factor for social regression in ASD. A stepwise experimental approach to this problem requires an animal model to provoke seizures and monitor subsequent behavior. We used rats of the Krushinsky-Molodkina (KM) strain as a validated inbred genetic model for human temporal lobe epilepsy, with recently described social deficiency and hypolocomotion. Generalized tonic-clonic seizures in KM rats are sound-triggered, thus being controlled events in drug-naïve animals. We studied whether seizure experience would aggravate contact deficits in these animals. Locomotor and contact parameters were registered in "the elevated plus maze", "socially enriche

SUBMITTER: Rebik A 

PROVIDER: S-EPMC10526393 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature