Altered Metabolic Networks in Mesial Temporal Lobe Epilepsy with Focal to Bilateral Seizures.

ABSTRACT: This study was designed to identify whether the metabolic network changes in mesial temporal lobe epilepsy (MTLE) patients with focal to bilateral tonic-clonic seizures (FBTCS) differ from changes in patients without FBTCS. This retrospective analysis enrolled 30 healthy controls and 54 total MTLE patients, of whom 27 had FBTCS. Fluorodeoxyglucose positron emission tomography (FDG-PET) data and graph theoretical analyses were used to examine metabolic connectivity. The differences in metabolic networks between the three groups were compared. Significant changes in both local and global network topology were evident in FBTCS+ patients as compared to healthy controls, with a lower assortative coefficient and altered betweenness centrality in 15 brain regions. While global network measures di

SUBMITTER: Guo Z 

PROVIDER: S-EPMC10526398 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature