Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.

ABSTRACT: Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling. TRPC3 is highly expressed in the brain and also found in endocrine tissues and smooth muscle cells. The channel is activated directly by binding of diacylglycerol downstream of G-protein coupled receptor activation. In addition, TRPC3 is regulated by endogenous factors including Ca²⁺ ions, other endogenous lipids, and interacting proteins. The molecular and structural mechanisms underlying activation and regulation of TRPC3 are incompletely understood. Recently, several high-resolution cryogenic electron microscopy structures of TRPC3 and the closely related channel TRPC6 have been resolved in different functional states and in

SUBMITTER: Cole BA 

PROVIDER: S-EPMC10526463 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature