Zeb1 Regulates the Function of Lympho-Myeloid Primed Progenitors after Transplantation.

ABSTRACT: Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal (EMT) transcription factor, acts as a critical regulator of hematopoietic stem cell (HSC) self-renewal and multi-lineage differentiation. Whether Zeb1 directly regulates the function of multi-potent progenitors primed for hematopoietic lineage commitment remains ill defined. By using an inducible Mx-1 Cre conditional mouse model where Zeb1 was genetically engineered to be deficient in the adult hematopoietic system (hereafter Zeb1^-/-), we found that the absolute cell number of immunophenotypically defined lympho-myeloid primed progenitors (LMPPs) from Zeb1^-/- mice was reduced. Myeloid- and lymphoid-biased HSCs in Zeb1^-/- mice were unchanged, im

SUBMITTER: Almotiri A 

PROVIDER: S-EPMC10526482 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature