PD-L1 Expression in Pituitary Neuroendocrine Tumors/Pituitary Adenomas.

ABSTRACT:

Background and aim

About a third of Pituitary Neuroendocrine Tumors (PitNETs) may show aggressive behavior. Many efforts have been performed for identifying possible predictive factors to early determine the future behavior of PitNETs. Programmed cell death ligand 1 (PD-L1) expression was associated with a more aggressive biology in different solid tumors, but its role in PitNET is not well-established yet. Our study aims to analyze PD-L1 expression in a surgical cohort of PitNETs to determine its association with radiological invasion and pathology findings, as well as with long-term recurrence rates.

Methods

We performed a retrospective analysis in a series of 86 PitNETs. Clinical presentation and radiological features of the preoperative period were collected, as well as

SUBMITTER: Cossu G 

PROVIDER: S-EPMC10526513 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature