Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification.

ABSTRACT: Background: The introduction of magnetic resonance (MR)-guided radiation treatment planning has opened a new space for theranostic nanoparticles to reduce acute toxicity while improving local control. In this work, second-generation AGuIX^® nanoparticles (AGuIX-Bi) are synthesized and validated. AGuIX-Bi are shown to maintain MR positive contrast while further amplifying the radiation dose by the replacement of some Gd³⁺ cations with higher Z Bi³⁺. These next-generation nanoparticles are based on the AGuIX^® platform, which is currently being evaluated in multiple Phase II clinical trials in combination with radiotherapy. Methods: In this clinically scalable methodology, AGuIX^® is used as an initial chelation platform to ex

SUBMITTER: Brown N 

PROVIDER: S-EPMC10526655 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature