Reassessing surgical guidelines for papillary thyroid cancer impact on survival: Expanding indications for lobectomy.

ABSTRACT:

Background

Comparisons of lobectomy versus total thyroidectomy for papillary thyroid cancer have not addressed significant threats to valid inference from observational data. The purpose of this study was to compare survival after lobectomy versus total thyroidectomy for papillary thyroid cancer while addressing bias from unmeasured confounding.

Methods

This retrospective cohort study included 84,300 patients treated with lobectomy or total thyroidectomy for papillary thyroid cancer in the National Cancer Database from 2004 to 2017. The primary outcome was overall survival evaluated by flexible parametric survival models and inverse probability weighting on the propensity score. Bias from unobserved confounding was assessed using two-way deterministic sensitivity analysis an

SUBMITTER: Stevens A 

PROVIDER: S-EPMC10526679 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature