Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity.

ABSTRACT:

Objective

To establish conditions for effective hypothalamic suppression in women with normal and high body mass index (BMI) and test the hypothesis that intravenous (IV) administration of pulsatile recombinant follicle-stimulating hormone (rFSH) can overcome the clinically evident dysfunctional pituitary-ovarian axis in women with obesity.

Design

Prospective interventional study.

Setting

Academic medical center.

Patient(s)

Twenty-seven normal-weight women and 27 women with obesity, who were eumenorrheic and aged 21-39 years.

Intervention(s)

Two-day frequent blood sampling study, in early follicular phase, before and after cetrorelix suppression of gonadotropins and exogenous pulsatile IV rFSH administration.

Main outcome measure(s)

Serum inhibin

SUBMITTER: Luu TH 

PROVIDER: S-EPMC10526695 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature