Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model.

ABSTRACT:

Background

Hemorrhage accounts for 40% of the preventable death following severe injury. Activation of systemic coagulation produces bradykinin (BK), which may cause leak from the plasma to the extravascular space and to the tissues, which is part of the complex pathophysiology of trauma-induced end-organ injury. We hypothesize that BK, released during activation of coagulation in severe injury, induces pulmonary alveolar leak.

Methods

Isolated neutrophils (PMNs) were pretreated with a specific BK receptor B2 antagonist HOE-140/icatibant and BK priming of the PMN oxidase was completed. Rats underwent tissue injury/hemorrhagic shock (TI/HS), TI/icatibant/HS, and controls (no injury). Evans blue dye was instilled, and the percentage leak from the plasma to the lung was calcula

SUBMITTER: Eitel A 

PROVIDER: S-EPMC10526729 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature