Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.

ABSTRACT: Genome stability in human cells relies on the efficient repair of double-stranded DNA breaks, which is mainly achieved by homologous recombination (HR). Among the regulators of various cellular functions, Protein phosphatase 4 (PP4) plays a pivotal role in coordinating cellular response to DNA damage. Meanwhile, Centrobin (CNTRB), initially recognized for its association with centrosomal function and microtubule dynamics, has sparked interest due to its potential contribution to DNA repair processes. In this study, we investigate the involvement of PP4 and its interaction with CNTRB in HR-mediated DNA repair in human cells. Employing a range of experimental strategies, we investigate the physical interaction between PP4 and CNTRB and shed light on the importance of two specific motifs in C

SUBMITTER: Rethi-Nagy Z 

PROVIDER: S-EPMC10526779 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature