Targeting MET Amplification: Opportunities and Obstacles in Therapeutic Approaches.

ABSTRACT: The MET gene plays a vital role in cellular proliferation, earning it recognition as a principal oncogene. Therapies that target MET amplification have demonstrated promising results both in preclinical models and in specific clinical cases. A significant obstacle to these therapies is the ability to distinguish between focal amplification and polysomy, a task for which simple MET copy number measurement proves insufficient. To effectively differentiate between the two, it is crucial to utilize comparative measures, including in situ hybridization (ISH) with the centromere or next generation sequencing (NGS) with adjacent genes. Despite the promising potential of MET amplification treatment, the judicious selection of patients is paramount to maximize therapeuti

SUBMITTER: Kumaki Y 

PROVIDER: S-EPMC10526812 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature