Redox Metabolism and Vascular Calcification in Chronic Kidney Disease.

ABSTRACT: Vascular calcification (VC) is a common complication in patients with chronic kidney disease which increases their mortality. Although oxidative stress is involved in the onset and progression of this disorder, the specific role of some of the main redox regulators, such as catalase, the main scavenger of H₂O₂, remains unclear. In the present study, epigastric arteries of kidney transplant recipients, a rat model of VC, and an in vitro model of VC exhibiting catalase (Cts) overexpression were analysed. Pericalcified areas of human epigastric arteries had increased levels of catalase and cytoplasmic, rather than nuclear runt-related transcription factor 2 (RUNX2). In the rat model, advanced aortic VC concurred with lower levels of the H₂O₂-scaveng

SUBMITTER: Carrillo-Lopez N 

PROVIDER: S-EPMC10526886 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature