Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis.

ABSTRACT: Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead to complications with long-term use. Recent studies have focused on identifying promising medications administered epidurally to affected spinal regions. In this study, we aimed to investigate the effectiveness of harpagoside (HAS) as an epidural medication in rats with LSS. HAS at various concentrations was effective for neuroprotection against ferrous sulfate damage and consequent promotion of axonal outgrowth in primary spinal cord neurons. When two concentrations of HAS (100 and 200 μg/kg) w

SUBMITTER: Hong JY 

PROVIDER: S-EPMC10526993 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature