Rare Variants in Primary Immunodeficiency Genes and Their Functional Partners in Severe COVID-19.

ABSTRACT: The development of severe COVID-19, which is a complex multisystem disease, is thought to be associated with many genes whose action is modulated by numerous environmental and genetic factors. In this study, we focused on the ideas of the omnigenic model of heritability of complex traits, which assumes that a small number of core genes and a large pool of peripheral genes expressed in disease-relevant tissues contribute to the genetics of complex traits through interconnected networks. We hypothesized that primary immunodeficiency disease (PID) genes may be considered as core genes in severe COVID-19, and their functional partners (FPs) from protein-protein interaction networks may be considered as peripheral near-core genes. We used whole-exome sequencing data from patients aged ≤ 45 year

SUBMITTER: Khadzhieva MB 

PROVIDER: S-EPMC10526997 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature