TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas.

ABSTRACT: This study investigates the expression and prognostic value of TRIM6 in gliomas, the most prevalent primary brain and spinal cord tumors. Our results show that TRIM6 is predominantly overexpressed in glioma tissues and is associated with reduced overall survival, disease-specific survival, and progression-free interval. Furthermore, TRIM6 expression is correlated with WHO grade and primary treatment outcomes. Functional analysis indicates that interactions between cytokines and their receptors play a critical role in the prognosis of glioma patients. A protein-protein interaction network reveals 10 hub genes closely linked to cytokine-cytokine receptor interaction. In vitro experiments demonstrate that silencing TRIM6 impairs the proliferation, invasion, and migration of glioma cells, whil

SUBMITTER: Guo J 

PROVIDER: S-EPMC10527026 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature