The Interaction of Borrelia burgdorferi with Human Dendritic Cells: Functional Implications.

ABSTRACT: Dendritic cells bridge the innate and adaptive immune responses by serving as sensors of infection and as the primary APCs responsible for the initiation of the T cell response against invading pathogens. The naive T cell activation requires the following three key signals to be delivered from dendritic cells: engagement of the TCR by peptide Ags bound to MHC molecules (signal 1), engagement of costimulatory molecules on both cell types (signal 2), and expression of polarizing cytokines (signal 3). Initial interactions between Borrelia burgdorferi, the causative agent of Lyme disease, and dendritic cells remain largely unexplored. To address this gap in knowledge, we cultured live B. burgdorferi with monocyte-derived dendritic cells (mo-DCs) from healthy donors to examine the bacterial imm

SUBMITTER: Gutierrez-Hoffmann M 

PROVIDER: S-EPMC10527078 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature