Ultra-high dose-rate proton FLASH improves tumor control.

ABSTRACT:

Background and purpose

Proton radiotherapy (PRT) offers potential benefits over other radiation modalities, including photon and electron radiotherapy. Increasing the rate at which proton radiation is delivered may provide a therapeutic advantage. Here, we compared the efficacy of conventional proton therapy (CONV^pr) to ultrahigh dose-rate proton therapy, FLASH^pr, in a mouse model of non-small cell lung cancers (NSCLC).

Materials and methods

Mice bearing orthotopic lung tumors received thoracic radiation therapy using CONV^pr (<0.05 Gy/s) and FLASH^pr (>60 Gy/s) dose rates.

Results

Compared to CONV^pr, FLASH^pr was more effective in reducing tumor burden and decreasing tumor cell proliferation. Furthermore,

SUBMITTER: Shukla S 

PROVIDER: S-EPMC10527231 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature