EGF-Receptor-Dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis.

ABSTRACT: Glomerulonephritis (GN) is a group of inflammatory diseases and an important cause of morbidity and mortality worldwide. The initiation of the inflammatory process is quite different for each type of GN; however, each GN is characterized commonly and variably by acute inflammation with neutrophils and macrophages and crescent formation, leading to glomerular death. Toll-like receptor (TLR) 7 is a sensor for self-RNA and implicated in the pathogenesis of human and murine GN. Here, we show that TLR7 exacerbates glomerular injury in nephrotoxic serum nephritis (NTN), a murine model of severe crescentic GN. TLR7^-/- mice were resistant to NTN, although TLR7^-/- mice manifested comparable immune-complex deposition to wild-type mice without significant defects in humoral immu

SUBMITTER: Tatsumoto N 

PROVIDER: S-EPMC10527264 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature