Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function.

ABSTRACT:

Objective

Skeletal muscle quality and mass are important for maintaining physical function during advancing age. We leveraged baseline data from Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) to evaluate whether paraspinal muscle density and muscle area are associated with cardiac or physical function outcomes in people with HIV (PWH).

Methods

REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in PWH. This cross-sectional analysis focuses on participants who underwent coronary computed tomography at baseline. Lower thoracic paraspinal muscle density (Hounsfield units [HU]) and area (cm 2 ) were assessed on noncontrast computed tomography.

Results

Of 805 PWH, 708

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC10527277 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature