Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.

ABSTRACT:

Background

Tobacco smoking increases frailty risk among the general population and is common among people with HIV (PWH) who experience higher rates of frailty at younger ages than the general population.

Methods

We identified 8608 PWH across 6 Centers for AIDS Research Network of Integrated Clinical Systems sites who completed ≥2 patient-reported outcome assessments, including a frailty phenotype measuring unintentional weight loss, poor mobility, fatigue, and inactivity, and scored 0-4. Smoking was measured as baseline pack-years and time-updated never, former, or current use with cigarettes/day. We used Cox models to associate smoking with risk of incident frailty (score ≥3) and deterioration (frailty score increase by ≥2 points), adjusted for demographics, antiretroviral

SUBMITTER: Ruderman SA 

PROVIDER: S-EPMC10527292 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature