Neuroimaging of social motivation during winning and losing: Associations with social anhedonia across the psychosis spectrum.

ABSTRACT:

Background

Individuals with psychosis spectrum disorders (PSD) have difficulty developing social relationships. This difficulty may reflect reduced response to social feedback involving functional alterations in brain regions that support the social motivation system: ventral striatum, orbital frontal cortex, insula, dorsal anterior cingulate cortex, and amygdala. Whether these alterations span PSD is unknown.

Methods

71 individuals with PSD, 27 unaffected siblings, and 37 control participants completed a team-based fMRI task. After each trial, participants received performance feedback paired with the expressive face of a teammate or opponent. A 2 × 2 (win versus loss outcome x teammate versus opponent) repeated measures ANOVA by group was performed on activation in the fiv

SUBMITTER: Jimenez AM 

PROVIDER: S-EPMC10527321 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature