Electric Field Effects on Brain Activity: Implications for Epilepsy and Burst Suppression.

ABSTRACT: Electric fields are now considered a major mechanism of epileptiform activity. However, it is not clear if another electrophysiological phenomenon, burst suppression, utilizes the same mechanism for its bursting phase. Thus, the purpose of this study was to compare the role of ephaptic coupling-the recruitment of neighboring cells via electric fields-in generating bursts in epilepsy and burst suppression. We used local injections of the GABA-antagonist picrotoxin to elicit epileptic activity and a general anesthetic, sevoflurane, to elicit burst suppression in rabbits. Then, we applied an established computational model of pyramidal cells to simulate neuronal activity in a 3-dimensional grid, with an additional parameter to trigger a suppression phase based on extra-cellular calcium dynami

SUBMITTER: Doubovikov ED 

PROVIDER: S-EPMC10527339 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature