The NQR Complex Regulates the Immunomodulatory Function of Bacteroides thetaiotaomicron.

ABSTRACT: The gut microbiome and intestinal immune system are engaged in a dynamic interplay that provides myriad benefits to host health. However, the microbiome can also elicit damaging inflammatory responses, and thus establishing harmonious immune-microbiome interactions is essential to maintain homeostasis. Gut microbes actively coordinate the induction of anti-inflammatory responses that establish these mutualistic interactions. Despite this, the microbial pathways that govern this dialogue remain poorly understood. We investigated the mechanisms through which the gut symbiont Bacteroides thetaiotaomicron exerts its immunomodulatory functions on murine- and human-derived cells. Our data reveal that B. thetaiotaomicron stimulates production of the cytokine IL-10 via secreted factors that are pa

SUBMITTER: Engelhart MJ 

PROVIDER: S-EPMC10527448 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature