Dopaminergic modulation by quercetin: In silico and in vivo evidence using Caenorhabditis elegans as a model.

ABSTRACT: Quercetin is a flavonol widely distributed in plants and has various described biological functions. Several studies have reported on its ability to restore neuronal function in a wide variety of disease models, including animal models of neurodegenerative disorders such as Parkinson's disease. Quercetin per se can act as a neuroprotector/neuromodulator, especially in diseases related to impaired dopaminergic neurotransmission. However, little is known about how quercetin interacts with the dopaminergic machinery. Here we employed the nematode Caenorhabditis elegans to study this putative interaction. After observing behavioral modulation, mutant analysis and gene expression in C. elegans upon exposure to quercetin at a concentration that does not protect against MPTP, we constructed a hom

SUBMITTER: Salgueiro WG 

PROVIDER: S-EPMC10527449 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature