Calcium-triggered DNA-mediated membrane fusion in synthetic cells.

ABSTRACT: In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

SUBMITTER: Hsu YY 

PROVIDER: S-EPMC10527479 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature