Synaptic variance and action potential firing of cerebellar output neurons during motor learning in larval zebrafish.

ABSTRACT: The cerebellum regulates both reflexive and acquired movements. Here, by recording voltage-clamped synaptic currents and spiking in cerebellar output (eurydendroid) neurons in immobilized larval zebrafish, we investigated synaptic integration during reflexive movements and throughout associative motor learning. Spiking coincides with the onset of reflexive fictive swimming but precedes learned swimming, suggesting that eurydendroid signals may facilitate the initiation of acquired movements. Although firing rates increase during swimming, mean synaptic inhibition greatly exceeds mean excitation, indicating that learned responses cannot result solely from changes in synaptic weight or upstream excitability that favor excitation. Estimates of spike threshold crossings based on measurements o

SUBMITTER: Najac M 

PROVIDER: S-EPMC10527510 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature