Inheritance-Specific Dysregulation of Th1- and Th17-Associated Cytokines in Alopecia Areata.

ABSTRACT: Autoimmune diseases tend to cluster in families, suggesting genetic predisposition to autoimmunity associated with familial background. We have previously reported similarities in gene expression patterns and PTPN22 polymorphisms between alopecia areata (AA) patients and their healthy relatives, but not unrelated healthy controls. However, the spectrum of disease promoting (or preventing) pathways that may be activated in blood relatives of AA patients remains to be defined. Here, we investigated the extent to which cytokines associated with the Th1 and Th17 pathway are differentially expressed in the blood of patients with AA and its clinical subtypes in comparison to both healthy relatives as well as unrelated healthy controls. A comprehensive set of Th1- and Th17-related cytokines were

SUBMITTER: Van Acker MM 

PROVIDER: S-EPMC10527519 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature