Invariant neural dynamics drive commands to control different movements.

ABSTRACT: It has been proposed that the nervous system has the capacity to generate a wide variety of movements because it reuses some invariant code. Previous work has identified that dynamics of neural population activity are similar during different movements, where dynamics refer to how the instantaneous spatial pattern of population activity changes in time. Here, we test whether invariant dynamics of neural populations are actually used to issue the commands that direct movement. Using a brain-machine interface (BMI) that transforms rhesus macaques' motor-cortex activity into commands for a neuroprosthetic cursor, we discovered that the same command is issued with different neural-activity patterns in different movements. However, these different patterns were predictable, as we found that the

SUBMITTER: Athalye VR 

PROVIDER: S-EPMC10527529 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature