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New Glycosalen-Manganese(III) Complexes and RCA₁₂₀ Hybrid Systems as Superoxide Dismutase/Catalase Mimetics.

ABSTRACT: Reactive oxygen species are implicated in several human diseases, including neurodegenerative disorders, cardiovascular dysfunction, inflammation, hereditary diseases, and ageing. Mn^III-salen complexes are superoxide dismutase (SOD) and catalase (CAT) mimetics, which have shown beneficial effects in various models for oxidative stress. These properties make them well-suited as potential therapeutic agents for oxidative stress diseases. Here, we report the synthesis of the novel glycoconjugates of salen complex, EUK-108, with glucose and galactose. We found that the complexes showed a SOD-like activity higher than EUK-108, as well as peroxidase and catalase activities. We also investigated the conjugate activities in the presence of Ricinus communis agglutinin (RCA₁₂₀) lectin. The hybrid protein-galactose-EUK-108 system showed an increased SOD-like activity similar to the native SOD1.

SUBMITTER: Lanza V

PROVIDER: S-EPMC10527547 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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New Glycosalen-Manganese(III) Complexes and RCA<sub>120</sub> Hybrid Systems as Superoxide Dismutase/Catalase Mimetics.

Lanza Valeria V Vecchio Graziella G

Biomimetics (Basel, Switzerland) 20230921 5

Reactive oxygen species are implicated in several human diseases, including neurodegenerative disorders, cardiovascular dysfunction, inflammation, hereditary diseases, and ageing. Mn<sup>III</sup>-salen complexes are superoxide dismutase (SOD) and catalase (CAT) mimetics, which have shown beneficial effects in various models for oxidative stress. These properties make them well-suited as potential therapeutic agents for oxidative stress diseases. Here, we report the synthesis of the novel glycoc ...[more]

PMID: 37754198

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