Predictive Value of Serum Biomarkers for Response of Limited-Stage AIDS-Associated Kaposi Sarcoma to Antiretroviral Therapy With or Without Concomitant Chemotherapy in Resource-Limited Settings.

ABSTRACT:

Background

Guidelines for limited-stage human immunodeficiency virus-associated Kaposi sarcoma (AIDS/KS) recommend antiretroviral therapy (ART) as initial treatment. However, many such individuals show worsening KS and require additional chemotherapy. Methods to identify such patients are lacking.

Setting

We studied whether serum levels of biomarkers associated with angiogenesis, systemic inflammation, and immune activation, which are elevated in HIV-infected individuals and implicated in the development of KS, could prospectively identify individuals with limited-stage AIDS-KS who would benefit from chemotherapy administered with ART.

Methods

Serum specimens were obtained from participants in a randomized trial evaluating the value of adding oral etoposide chemothera

SUBMITTER: Epeldegui M 

PROVIDER: S-EPMC10527582 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature