A PhysioMechanical Model of Esophageal Function in Eosinophilic Esophagitis.

ABSTRACT:

Background & aims

Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation, but also heterogeneous presentations involving fibrostenotic esophageal remodeling and esophageal dysmotility. We aimed to define and evaluate phenotypes of EoE using functional lumen imaging probe (FLIP) panometry (ie, a PhysioMechanical classification of EoE).

Methods

Patients with EoE who completed FLIP during endoscopy were included in a cross-sectional study. FLIP studies were analyzed for distensibility plateau and compliance of the esophageal body, maximum esophagogastric junction diameter, and contractile response pattern. These FLIP features were then applied to define PhysioMechanical classifications.

Results

A total of 215 patients with EoE (mean [standard deviat

SUBMITTER: Carlson DA 

PROVIDER: S-EPMC10527622 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature