Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.

ABSTRACT: Gastroentero-pancreatic Neuroendocrine Neoplasms (GEP-NENs) are a diverse group of rare tumors that arise from neuroendocrine cells in the gastrointestinal tract and pancreas, and they can vary significantly in terms of clinical behavior and prognosis. Immunotherapy, particularly immune checkpoint inhibitors, has shown remarkable success in various malignancies by harnessing the body's immune system to target and eliminate cancer cells. Immune checkpoint inhibitor clinical studies in GEP-NENs have yielded promising outcomes, particularly in individuals with advanced and refractory disease. Objective responses and disease stabilization have been observed in some cases, even in those previously unresponsive to traditional treatments like chemotherapy or targeted therapies. However, it's impo

SUBMITTER: Kaur J 

PROVIDER: S-EPMC10527684 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature