Exploring the relationship between history of infertility and the experience of menopausal symptoms.

ABSTRACT:

Objective

The aim of the study is to examine longitudinal associations of history of infertility with menopausal symptoms in midlife.

Methods

Six hundred ninety-five midlife women (≥45 y old or reporting ≥12 mo of amenorrhea at the midlife visit) in Project Viva, a prospective cohort enrolled 1999-2002 during pregnancy and followed for 18 years after enrollment ("midlife visit"). Exposure was history of infertility defined as time to pregnancy ≥12 months (≥6 mo if ≥35 y), use of medical treatment to conceive, or infertility consultation or treatment in the 6-month preceding enrollment. The primary outcome was score below or above the median on the Menopause Rating Scale (MRS). Secondary outcomes included individual symptom score on the MRS and self-reported age of menopause.

SUBMITTER: Fitz VW 

PROVIDER: S-EPMC10527707 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature