Are individual-level risk factors for gastroschisis modified by neighborhood-level socioeconomic factors?

ABSTRACT:

Background

Two strong risk factors for gastroschisis are young maternal age (<20 years) and low/normal pre-pregnancy body mass index (BMI), yet the reasons remain unknown. We explored whether neighborhood-level socioeconomic position (nSEP) during pregnancy modified these associations.

Methods

We analyzed data from 1269 gastroschisis cases and 10,217 controls in the National Birth Defects Prevention Study (1997-2011). To characterize nSEP, we applied the neighborhood deprivation index and used generalized estimating equations to calculate odds ratios and relative excess risk due to interaction.

Results

Elevated odds of gastroschisis were consistently associated with young maternal age and low/normal BMI, regardless of nSEP. High-deprivation neighborhoods modified the

SUBMITTER: Neo DT 

PROVIDER: S-EPMC10527855 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature