The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage Plasticity.

ABSTRACT: Lineage plasticity, a process whereby cells change their phenotype to take on a different molecular and/or histologic identity, is a key driver of cancer progression and therapy resistance. Although underlying genetic changes within the tumor can enhance lineage plasticity, it is predominantly a dynamic process controlled by transcriptional and epigenetic dysregulation. This review explores the transcriptional and epigenetic regulators of lineage plasticity and their interplay with other features of malignancy, such as dysregulated metabolism, the tumor microenvironment, and immune evasion. We also discuss strategies for the detection and treatment of highly plastic tumors.

Significance

Lineage plasticity is a hallmark of cancer and a critical facilitator of other oncogenic features

SUBMITTER: Davies A 

PROVIDER: S-EPMC10527883 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature