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Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D₃ in vivo.

ABSTRACT: Phosphate (P) is an essential element involved in various biological actions, such as bone integrity, energy production, cell signaling and molecular component. P homeostasis is modulated by 4 main tissues; intestine, kidney, bone, and parathyroid gland, where 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃), parathyroid hormone and fibroblast growth factor 23 (FGF23) are produced and/or have an influence. In bone, serum P level modulates the production of FGF23 which then controls not only P excretion but also vitamin D metabolism in kidney in an endocrine manner. The hormonally active form of vitamin D, 1,25(OH)₂D₃, also has a significant effect on skeletal cells via its receptor, the vitamin D receptor, to control gene expression which mediat

SUBMITTER: Lee SM

PROVIDER: S-EPMC10527973 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Dataset Information

Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D₃ in vivo.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D3 in vivo.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Genome-wide analyses of gene expression profile identify key genes and pathways involved in skeletal response to phosphate and 1,25-dihydroxyvitamin D₃ in vivo.