The potential of intervening on childhood adversity to reduce socioeconomic inequities in body mass index and inflammation among Australian and UK children: A causal mediation analysis.

ABSTRACT:

Background

Lower maternal education is associated with higher body mass index (BMI) and higher chronic inflammation in offspring. Childhood adversity potentially mediates these associations. We examined the extent to which addressing childhood adversity could reduce socioeconomic inequities in these outcomes.

Methods

We analysed data from two early-life longitudinal cohorts: the Longitudinal Study of Australian Children (LSAC; n=1873) and the UK Avon Longitudinal Study of Parents and Children (ALSPAC; n=7085).

Exposure

low/medium (below university degree) versus high maternal education, as a key indicator of family socioeconomic position (0-1 year).

Outcomes

BMI and log-transformed glycoprotein acetyls (GlycA) (LSAC: 11-12 years; ALSPAC: 15.5 years). Mediator:

SUBMITTER: Priest N 

PROVIDER: S-EPMC10527996 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature