Antidepressant effects of acute sleep deprivation are reduced in highly controlled environments.

ABSTRACT:

Background

Numerous studies summarized in a recent meta-analysis have shown sleep deprivation rapidly improves depressive symptoms in approximately 50 % of individuals with major depressive disorder (MDD), however those studies were typically conducted in clinical settings. Here we investigated the effects of sleep deprivation utilizing a highly controlled experimental approach.

Methods

36 antidepressant-free individuals with MDD and 10 healthy controls (HC) completed a 5 day/4-night protocol consisting of adaptation, baseline, total sleep deprivation (TSD), and recovery phases. Light was kept consistently dim (≤50 lx), meals were regulated, and activity was restricted. In-the-moment mood was assessed using a modified Hamilton Rating Scale for Depression (HRSD) at screening

SUBMITTER: Goldschmied JR 

PROVIDER: S-EPMC10528033 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature