Prolonged experimental sleep disturbance affects the inflammatory resolution pathways in healthy humans.

ABSTRACT:

Background

Sleep disturbances, as manifested in insomnia symptoms of difficulties falling asleep or frequent nighttime awakenings, are a strong risk factor for a diverse range of diseases involving immunopathology. Low-grade systemic inflammation has been frequently found associated with sleep disturbances and may mechanistically contribute to increased disease risk. Effects of sleep disturbances on inflammation have been observed to be long lasting and remain after recovery sleep has been obtained, suggesting that sleep disturbances may not only affect inflammatory mediators, but also the so-called specialized pro-resolving mediators (SPMs) that actively resolve inflammation. The goal of this investigation was to test for the first time whether the omega-3 fatty acid-derived D- (R

SUBMITTER: Engert LC 

PROVIDER: S-EPMC10528069 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature