Association of clinical characteristics with urine uromodulin in children with chronic kidney disease.

ABSTRACT:

Background

Uromodulin is the most abundant protein in the urine of healthy adults, and higher urine concentrations mark better tubular health. Greater kidney size and function are predictors of higher uromodulin levels in adults. Urine uromodulin has not yet been studied in children with chronic kidney disease (CKD). Thus, we sought to determine the relationship between age and kidney function with urine uromodulin levels in children with CKD.

Methods

In the CKD in Children (CKiD) cohort, we utilized multivariable linear regression to evaluate the relationship of age and eGFR with urine uromodulin levels. The primary outcome was uromodulin indexed to urine creatinine (Umod/Cr, mg/g), which was log₂-transformed given its skewed distribution.

Results

Among 67

SUBMITTER: Faulkner SC 

PROVIDER: S-EPMC10528151 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature