Modeling and countering the effects of cosmic radiation using bioengineered human tissues.

ABSTRACT: Cosmic radiation is the most serious risk that will be encountered during the planned missions to the Moon and Mars. There is a compelling need to understand the effects, safety thresholds, and mechanisms of radiation damage in human tissues, in order to develop measures for radiation protection during extended space travel. As animal models fail to recapitulate the molecular changes in astronauts, engineered human tissues and "organs-on-chips" are valuable tools for studying effects of radiation in vitro. We have developed a bioengineered tissue platform for studying radiation damage in individualized settings. To demonstrate its utility, we determined the effects of radiation using engineered models of two human tissues known to be radiosensitive: engineered cardiac tissues (eCT, a targe

SUBMITTER: Tavakol DN 

PROVIDER: S-EPMC10528250 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature