Iron-Catalyzed Reductive Cross-Coupling of Alkyl Electrophiles with Olefins.

ABSTRACT: In terms of its abundance and its minimal toxicity, iron has advantages relative to other transition metals. Although alkyl-alkyl bond construction is central to organic synthesis, examples of iron-catalyzed alkyl-alkyl couplings of alkyl electrophiles are relatively sparse. Herein we report an iron catalyst that achieves cross-coupling reactions of alkyl electrophiles wherein olefins, in the presence of a hydrosilane, are used in place of alkylmetal reagents. Carbon-carbon bond formation proceeds at room temperature, and the method employs commercially available components (Fe(OAc)₂ , Xantphos, and Mg(OEt)₂ ); interestingly, this set of reagents can be applied directly to a distinct hydrofunctionalization of olefins, hydroboration. Mechanistic studies are consistent

SUBMITTER: Tong X 

PROVIDER: S-EPMC10528270 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature