Long-term trajectories of ambulatory impairment in multiple sclerosis.

ABSTRACT:

Background

Ambulatory impairment is a common and complex manifestation of multiple sclerosis (MS), and longitudinal patterns are not well understood.

Objective

To characterize longitudinal walking speed trajectories in a general MS patient population and in those with early disease (⩽ 5 years from onset), identify subgroups with similar patterns, and examine associations with individual attributes.

Methods

Using a retrospective cohort study design, latent class growth analysis was applied to longitudinal timed 25-foot walk (T25-FW) data from 7683 MS patients, to determine T25-FW trajectories. Associations were evaluated between trajectory assignment and individual attributes. Analyses were repeated for 2591 patients with early disease.

Results

In the general pa

SUBMITTER: Gunzler DD 

PROVIDER: S-EPMC10528275 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature