Cardiac Progenitor Cell Exosomal miR-935 Protects against Oxidative Stress.

ABSTRACT: Oxidative stress-induced myocardial apoptosis and necrosis are critically involved in ischemic infarction, and several sources of extracellular vesicles appear to be enriched in therapeutic activities. The central objective was to identify and validate the differential exosome miRNA repertoire in human cardiac progenitor cells (CPC). CPC exosomes were first analyzed by LC-MS/MS and compared by RNAseq with exomes of human mesenchymal stromal cells and human fibroblasts to define their differential exosome miRNA repertoire (exo-miR^SEL). Proteomics demonstrated a highly significant representation of cardiovascular development functions and angiogenesis in CPC exosomes, and RNAseq analysis yielded about 350 different miRNAs; among the exo-miR^SEL population, miR-935 was co

SUBMITTER: Aguilar S 

PROVIDER: S-EPMC10528297 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature